The etiology and pathogenesis of diabetes mellitus

Causes of
What happens?
The causes of
Which leads
Heredity
To get rid of, avoid
Is curable?
The causes of the disease
Syndromes
Predisposition
Is there any report?
How to prevent?
Etiology and pathogenesis
How to get
Why does

 

the etiology and pathogenesis of diabetes mellitusGenetic factors

Among the etiological factors of diabetes mellitus can distinguish congenital predisposition transmitted by inheritance. First of all it is connected with inheritance of the HLA alley, which is responsible for defeat b-cells of the pancreas. If one parent has diabetes, then the child's risk of developing type 1 diabetes mellitus (insulin dependent) is 10% and the risk of symptoms type 2 diabetes (not insulin dependent) more than 80%. Viral infection as the etiology and pathogenesis of diabetes mellitus.

One of the causes of diabetes may be infection. This primarily refers to Coxsackievirus B3 and B4, cytomegalovirus, mengovirus, the virus entsefalomiokardita, reovirus and rubella. Noted that following epidemics of mumps in 1-2 years among children who survive the disease, dramatically increases the number of newly detected cases of diabetes. Previously it was thought that hepatitis can also cause diabetes, but further studies proved that although the hepatitis and effect on insulin metabolism, the direct cause of diabetes it is not.

Nutritional factors in both the etiology and pathogenesis of diabetes mellitus

the Consumption of excessive amounts of food, obesity lead to hypersecretion of insulin. In turn, the excess insulin concentration in the blood leads to reduction in the number of insulin receptors - insulin resistance. Along with a genetic predisposition that leads to violations of appetite and metabolism. That is why most diabetics are overweight, and the risk of symptoms first identified diabetes is much higher in obese people.

of the Toxic factor etiology and pathogenesis of diabetes mellitus

overeating etiology of diabetes mellitusthe drugs streptozocin, diazoxide, dye alloxan, vacor deratizator the some other chemical substances containing compounds of nitrozomocevina can damage b-cells of the pancreas and cause diabetes.

Autoimmune disorders

Insult (inflammation of the pancreas), and autoimmune spontaneous and induced disturbances loss of tolerance to antibodies b-cells and autoimmune reaction against b-cells of the pancreas.

Etiological and pathogenetic factors of diabetes mellitus 1-St and 2-nd type are so numerous and variable in each patient, most specialists tend to assume that there is a large number of different diseases that manifest similar symptoms, which on the basis of the similarity of clinical manifestations combined into a single group - diabetes.