Causes of diabetes insipidus, classification

Diet and nutrition
In children


diabetes insipidus causesdiabetes Insipidus (colloquially, "diabetes") - a disease that is caused by insufficient secretion of the hormone ADH, antidiuretic hormone (the effect of reduced renal sensitivity to the effects of this hormone).

Deficiency of ADH or decreased physiological role in the secretion causes a decrease of the reverse suction of liquid in the tubules of the kidney and excretion in the urine. Diabetes insipidus is accompanied by the release of large amounts of urine, unquenchable thirst, and General dehydration. It is a rare endocrine pathology occurring frequently in the 20-40 age group - both men and women. Often the cause of this disease is the result posteromarginal complications (20%).


Classification of diabetes insipidus

Classification of diabetes insipidus depends on the degree of violations:


At Central, neurogenic form all the basic infringements occur at the level of secretion of ADH by the hypothalamus, highlight it in the blood. Renal form is characterized by impairment of ADH, the cells of the tubules of the nephrons.

the Central form of diabetes insipidus has also varieties:


symptomatic Causes of diabetes insipidus can be a traumatic brain injury, tumor infiltration in the brain, meningoencephalitis, and it may be congenital - caused by a mutation of the gene of ADH.

Renal form of diabetes insipidus is relatively rare. Its causes are associated with the inferiority of the nephron or impaired receptor sensitivity to ADH - congenital, acquired as a result of drug or metabolic damage to the nephrons.

Central is more Frequently diagnosed form of diabetes, caused by primary or metastatic tumor, neurosurgical intervention, vascular, TB, malarial, syphilitic lesions, etc.

Idiopathic diabetes insipidus is characterized by the absence of organic lesions of the hypothalamus and pituitary, it may be the cause of the appearance of antibodies to cells that produce ADH.

Renal form of diabetes can be caused kidney failure, hypercalcemia, excess doses of lithium. Symptomatic form of the syndrome of Tungsten.