Steroidogenic diabetes mellitus

Type 1
2nd type


Steroidogenic diabetes mellitusSteroidogenic diabetes mellitus may appear from intake of preparations and medications causing additional secretion and in relation with some diseases like, for example, pituitary basophilia. This disease belongs to category of diabetes mellitus of 1st type, because it is insulin-dependent diabetes mellitus so it might be considered clinical form of diabetes of first type. Just like other clinic forms - pancreatic, adrenalin, thyroid, hypophyseal - this one is caused by changes of functioning of internal organs or in their qualities. Treatment of steroidogenic diabetes is carried out, in most cases, as the treatment of diabetes mellitus of type 2.

Thiazolidinediones and Glucophage are the main preparations, insulin may be injected, a combination of Glucophage and mixes. The clinic steroidogenic diabetes does not have any expressive symptoms, the form of the disease is light, glucosuria and hyperglycemia is not clear. In case the form of the disease is still light, the preparations of sulfonyluregroups are working well, but they lead to worsening of carbohydrate metabolism. Insulin facilitates beta-cells functioning during this period, and they are recovering. Also some preventive measures are carried out by means of small insulin doses, anabolic steroids are prescribed additionally by doctor and proteins are added to the main diet of the patient. Consumption of pure carbohydrates is limited.

Oral steroid contraceptives, diuretics and some other types of these medications and preparations may affect carbohydrate metabolism. Their continuous consumption may cause appearance of this disease. All diabetes period consists of six phases, and for the steroid one the first stage is absent, while all others are there. The injury of beta-cells takes place without any insulin secreting dysfunction, but later its secretion goes down; after that the tolerance to glucose is broke and after 90% of beta-cells die and insulin secretion stops completely because these cells change their structure.

The diagnosis ‘steroidogenic diabetes mellitus' is given at the increase of indicators of blood glucose level that are 11 and 6 mmol/L after the meals and before meals, in normal state, accordingly. In the beginning, they exclude the diseases, which belong to this group as well, but there are specific forms of this type of disease. After that, doctors define the form and type of specific disease that is represented according to its manifestations and symptoms. The therapy and disease treatment is divided into traditional and intensive. The second one is more effective, as it allows the patient's living in comfort, but it requires more self-control, which takes place three times more often. The first months of treatment are the most responsible because methods are very expensive.