Kidney diabetes and renal failure with diabetes

Renal failure


renal diabetesdiabetes Kidney is a disease caused by decreased ability of the kidneys to produce urine with higher osmolar concentration, which is associated with impaired sensitivity of the tubules to the action of antidiuretic hormone.

the Main cause of renal diabetes insipidus is considered to be genetically determined deficiency of the enzyme glucose-6-phosphatase. Known cases of nephrogenic diabetes in toxic renal tubulopathy with medical or chronic inflammatory diseases of the kidneys, and in severe lesions of the nervous system.

Renal diabetes is a rare disease, more common in children. But there are known cases of diagnosis of the disease and at the age of 20 years.

In this disease is disturbed homeostatic kidney, aimed at maintaining water-salt balance in the body, which leads to hyperlactatemia and fluctuations in osmotic pressure of blood plasma. These fluctuations especially high for young children, as they have not developed a sense of thirst. The loss of significant amounts of water in the body leads to the development of dehydration or toxicity.

Renal diabetes occurs in the first six months of a child's life strong diuresis, constipation, vomiting, fever. Volume of urine in a young child can reach up to 2 liters per day, older children - up to 5 liters. This condition can lead to convulsive States, malnutrition, stunted mental and physical development.

the Diagnosis of nephrogenic diabetes is based on clinical symptoms and confirmed by functional studies, based on the study sample for the concentration of urine. Treatment of nephrogenic diabetes insipidus is systematic in nature and aimed primarily at restoring water-salt balance. Patients are prescribed the intake of large amounts of fluid while taking sulfa diuretics to reduce urine output.


Renal failure in diabetes mellitus

renal failure in diabetes mellitusOne of the late complications of diabetes is diabetic nephropathy. This disease is considered one of the main causes of morbidity in patients with diabetes.

the Main factors that caused the development of renal failure in diabetes, are considered as long duration of diabetes, chronic hyperglycemia, dyslipidemia, arterial hypertension, heredity.

the Disease develops slowly and without symptoms. In the first stage of the disease microalbuminuria, there is an increasing amount of protein (microalbuminuria) in the urine, which can only be found in a special way. There is a complete lack of symptoms - blood pressure normal, no edema and pain. This stage of the disease is completely reversible. To restore kidney function using a well-established conservative treatment, including the following activities: compensation of blood sugar, normalization of blood pressure (ACE inhibitors), lipid metabolism correction, diet with restriction of protein, salt, alcohol.

the Second stage of development of kidney disease (stage proteinuria) is characterized by a decline in clubcool filtration that there is a significant increase in the number of protein (proteinuria) in the urine. While there are some clear signs that indicate the progression of the disease, - increased blood pressure, development of edema.

This phase demonstrates the irreversibility of developing diabetic nephropathy, which sooner or later lead to chronic renal failure. To cure the disease at this stage can not, can only slow the progression of the disease. The treatment is conservative method, including the same event, and that the treatment of nephropathy in the first stage.

Chronic renal failure characterized by persistent kidney dysfunction. Manifests obvious signs of intoxication - vomiting, nausea, itchy skin. The disease at this stage can not be cured, can only extend the period for a kidney transplant through regular hemodialysis and conservative treatment.

In order to prevent and detect the disease in its early stages is essential to control the level of glucose in the blood, to control and to prevent a sharp increase in blood pressure yearly urine test for the detection microalbuminuria.