Nephropathy, nephrogenic diabetes

Renal failure


General characteristics of the disease. Nephrogenic diabetes insipidus is a hereditary family disease, associated with an inability of renal tubules to produce urine with osmoticescoy density higher than that of the primary urine. The disease is transmitted by the female line through the dominant gene of the X chromosome.

Nephrogenic diabetesthe cause of the disease is the lack of sensitivity of receptors of the epithelium kidney to vasopressin. Such insensitivity is associated with the pathology of hereditary diseases in which receptor gene mutates. Additionally, nephrogenic diabetes can be a disease acquired as a consequence of sickle cell anemia, hypokalemia, urinary tract obstruction, hypercalcaemia.



the Symptoms are most pronounced men; women symptoms detected by detailed examination and study. Disease, received by heredity, is manifested immediately after birth and manifests itself in the form of periodical febrile States, which is impossible to remove any antipyretic drugs or antibiotics. Besides fever, the disease is accompanied by gastrointestinal disorder, vomiting, constipation, thirst, symptoms of dehydration. The most likely manifestation of fever and vomiting between the third and sixth months of life, when there is a transition from breastfeeding to feeding cow's milk.

does Not allow to diagnose the disease in infancy the absence of pathology on programmah which have been undertaken in the first year of life. Hypotension bladder and other organs of the collective system begins to emerge only after 1.5 years.


the Diagnosis

DiagnosisNephrogenic diabetes insipidus is diagnosed based on three parameters:

• family illness;
• not amenable to medical treatment polyuria and polydipsia;
• hyposthenuria and giperosmolarnosti blood.

the Final confirmation of the diagnosis is made after the introduction into the blood of pitressin and the lack of reaction of the organism, i.e. preserving the amount of urine output and the preservation of its low relative density.


the Treatment

nutragena Therapy for diabetes insipidus in thiazide diuretics. Also assigned the role of supplementing the funds of the prostaglandin synthesis inhibitors: aspirin, ibuprofen, and indomethacin. In addition to medications appoint a diet with restriction of consumption of table salt. The risk from taking medication is the side effects and the possibility of development of gastric ulcer in long-term medication.