Mody diabetes mellitus

Type 1
2nd type


MODY-diabetes - is diabetes, which is caused by genetic hereditary forms. The clinical course of these form of diseases have similar symptoms, so they are organized into a separate group.

Description of Mody disease

Mody diabetes mellitusDiabetes of mature type occurs in young people (modi - diabetes) less frequently. The basic common features of this disease are violations which are caused by mutated gene. He either encodes insulin, or it is responsible for the regulation, functioning and development of the cells of the pancreas. At the moment are revealed 8 genes that are involved in the development of this type of diabetes mellitus. They are responsible for different types of MODY, and hence for varying the frequency of occurrence, and clinical picture and therapeutic tactics.

First acronym MODY was used in 1975 and entered by R.Tattersall and S. Fajans to determine less-progressive diabetes that develops in young patients. This disease usually makes itself felt in children, adolescence or in men of young age. Reliably determine the presence of the disease can only be analyzed by molecular genetic studies. It can confirm the presence of mutations in the genes. Mody is revealed approximately in 2-5% of all cases of diabetes and in 50% in cases with presence of gestational disease.

Identification of the disease

Mody diabetes mellitusAdvanced diagnostic capabilities allow doctors to determine type of diabetes in 90% of cases. It is known that the disease of diabetes mellitus of 1st type is diagnosed in children and young people, and it leads to insulin deficiency. For its treatment replacement therapy is required. Diabetes mellitus of 2nd type occurs in obese people and the elderly, and it can be perfectly treated by anti-diabetic therapy by means of drugs. In the case of children Mody diabetes mellitus can increase to glucose level up to value of 8.0 mmol / l. "Honeymoon" can last more than two years, and it can be observed as labile flow of the disease as compensation of disease too. Often due to its soft nature, like in case of diabetes mellitus of 2nd type there reduction of the sensitivity to insulin loaded drugs can be present. The disease can be suspected if its debut came at a young age, patient has obesity and it is observed the presence of diabetes mellitus in at least in two generations.

Currently, studies are aimed to identify new variants of the disease. They will help evaluate the extent of disease, a form of clinical presentation, as well as the likelihood of cardiovascular complications. It is possible that gene therapy will be developed, which is already is in work process in many laboratories.