Diabetes insipidus medication

Diet and nutrition
In children


diabetes insipidus medicationtreatment diabetes insipidus good effects of hormone replacement correction. Previously, first of all, administer vasopressin, however this medication has a number of disadvantages. First of all, the inefficiency of oral administration of most peptides, including vasopressin. In addition, alarming low antidiuretic activity and local side-effects through the mucous membranes of the nose. Allowed the infusion of vasopressin subcutaneously; the period of validity from 3 to 6 hours. The positivity of this short-acting that the time has celebrated the restoration of function of the neurohypophysis and thus prevents water intoxication if the patient intravenous fluid flows. Vasopressin is used as the initial therapeutic agent if the patient has acute diabetes insipidus is unconscious.

Desmopressin for much longer prevents dehydration of body through urination (the duration of effect of 12 to 24 hours) and, unlike vasopressin, with its high Pressor activity, almost completely devoid of it. It is administered through the mucosa of the nose (intranasally), or by subcutaneous injection. This medicine is chosen in most cases diabetes insipidus.

Using lypressin because it is an aerosol, it is envisaged exclusively intranasally. One irrigation of the nasal mucosa causes antidiuretic effect for 4 to 6 hours.

it Should be noted that if the patient additionally suffers from an upper respiratory infection or allergic rhinitis, this reduces the effect of intranasal use. In this case, only the introduction of desmopressin subcutaneously. The same should be done if the patient is unconscious.

If the patient has diabetes insipidus there is a residual secretion of antidiuretic hormone (ADH) by the neurohypophysis, several non-hormonal means, oral.

Chlorpropamide is used to stimulate the hormone secretion and strengthen its impact on the renal tubule. It also returns a sick feeling thirsty. Medicine enough to take once a day, he begins to act in the first hours after administration, usually within 24 hours. There is a risk of hypoglycemia, but she is excluded if the patient maintains a regular diet.

Similar to chlorpropamide to stimulation of ADH secretion has a positive impact and clofibrate, but you will need to take four times a day. In the result of dehydration of the patient through urination steadfastly terminated.

In some cases, the combination treatment of patients with diabetes insipidus two above-mentioned medicines completely restored in their bodies the regulation of water metabolism.