Allergies diabetes

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Allergy diabetesmost Often an allergic reaction in diabetes mellitus are associated with reception of analog insulin preparations, or rather, with certain impurities they contain. Found that Allergy sufferers of diabetes directly cause drug molecules of animal origin, as well as preservatives and chemicals used to slow the action of insulin (e.g., zinc). The main cause of allergic reactions is high antigenic activity of the protein impurities of pig and cattle (bovine) insulin. And synthetic human insulin is less antigenic effect, and is therefore less allergenic.

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Symptoms

the Most typical manifestation of allergies in diabetes is reflected in local reaction to the drug. The injection site is formed papule or infiltrate (itchy, moderately painful seal, it is also possible swelling, redness, and in severe cases, necrosis). Because of pathogenetic the causes of this phenomenon can be different, it is customary to divide them into 3 types:

the First type (Arthus phenomenon). The reaction occurs within 5-8 hours after injection. There is a slight infiltration, itching, soreness.

the Second type (i.e. tuberculosis). The reaction occurs at least 12 hours after drug administration.

the Third kind (two-phase). 1 phase - redness, itching. Phase 2 - after about 6 hours the infiltrate is formed, which lasts for several days.

in Addition to local, there may be General symptoms of allergies in diabetes, such as angioedema, bronchospasm, urticaria. Quite often there are lesions of the mucous membranes, gastro-intestinal disorders. In some cases, a generalized form accompanied by falling long-term high temperature. With long-term use of animal insulin or medication with zinc typical complaints of joint and muscle pain. The extreme manifestation of Allergy - anaphylactic shock.

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Treatment

the Main goal of treatment of allergic manifestations in diabetes mellitus is to pick up the drug insulin, which will be suitable to a specific person. Most often you need to change the brand medicines. If the drug is replacing elusive, insulin is recommended to enter along with micro-doses of hydrocortisone. If the severity of Allergy in patients with diabetes mellitus it is advisable to conduct specific therapy with antihistamines (diphenhydramine, tavegil, suprastin, etc.). In severe forms requires advice and supervision at the allergist.